Categories: Drugs information

Lioresal (baclofen) belongs to the therapeutic class of centrally acting skeletal muscle relaxants and antispastics. 

The chemical class of the main component baclofen is gamma aminobutyric acid with the properties to inhibit monosynaptic and polysynaptic reflexes at the spinal level.

Lioresal is an analog of the putative inhibitory neurotransmitter gamma-aminobutyric acid (GABA).

In clinical studies of the medication it was confirmed that baclofen had general CNS depressant properties. It is rapidly absorbed in the body and eliminated primarily by the kidney in unmodified form.

Lioresal is available in dosage form of tablets for oral use containing 10 mg or 20 mg of the active component.

This medication is effectively used for facilitation of signs and symptoms of spasticity caused by multiple sclerosis. It relieves pain from flexor spasms and concomitant pain, clonus, and muscular rigidity.

Other medical purpose for this medication is use in patients with spinal cord injuries and in some patients with trigeminal neuralgia or severe pain along the nerves in the face.

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Only a medical professional can determine the right dose of this medication for each individual situation. The dose depends on the age of a patient, the condition being treated and other medical conditions a patient may have.

The treatment is usually initiated with the lowest effective dose. If necessary the dose is increased bit by bit to gain the needed effect. The daily dose is usually ranged from 40 up to 80 mg.

The max daily dose should not exceed 80 mg.


Lioresal dose for muscle relaxation:

Adults and children from 13 to 18 years of age are adjusted 5 mg three times a day. The following days the dose may be increased by 5 mg. The dose for younger children should be determined by doctor.

Before use of Lioresal it is necessary to get a doctor’s consultation. You should discuss your medical history with your doctor and tell him if you have: type II diabetes, epilepsy, and kidney disease, mental or emotional problems.  Discuss with your doctor the possibility of safe use of this medication if you have stroke or other brain disease.

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Lioresal should not be mixed with alcohol. Consumption of alcohol can increase the risk for side effects of baclofen.

This medication may affect thinking or reactions of a patient. A person taking this medication should be watchful for his health state and condition. Dangerous operations or driving should be avoided.

Baclofen may cause certain side effects, including: confusion, dizziness or lightheadedness, drowsiness, nausea, unusual weakness, muscle weakness.

Some side effects of this medication may be dangerous for a patient’s health. They require immediate medical assistance.

  • chest pain
  • fainting
  • hallucinations
  • ringing or buzzing in the ears
  • blurred or double vision
  • convulsions (seizures)
  • vomiting

Lioresal is an effective muscle relaxant, it is available only with a doctor’s prescription. Self-treatment with this medication may be harmful for a patient’s health.

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